THUMPD3

Across TCGA cell cohorts, THUMPD3 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible THUMPD3-associated genes across cancer lineages are GFRA4, LMX1A, and FAM187B. Each is linked with THUMPD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both THUMPD3-to-partner and partner-to-THUMPD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GFRA4 grouped by THUMPD3-low versus THUMPD3-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THUMPD3→partner) and Y-score (partner→THUMPD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GFRA4 →	+0.008	+3.714	.005	.006	3	1
BLOOD_Lymphoma	LMX1A →	+0.022	+3.714	.002	.006	3	1
BLOOD_Lymphoma	FAM187B →	+0.031	+4.058	<.001	.009	3	1
BLOOD_Lymphoma	OR5AK2 →	+0.038	+4.662	<.001	.003	3	1
OVARY	ASPA →	+0.070	+2.832	<.001	.004	3	1
OVARY	DAO →	+0.047	+3.000	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

GFRA4 by THUMPD3 expression — BLOOD_Lymphoma

Explore this box plot interactively →