THUMPD2

Across TCGA pan-cancer cohorts, THUMPD2 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated THUMPD2 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher THUMPD2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated THUMPD2 expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

LSCC, HNSC, and CCRCC are the cancer types where THUMPD2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	All	1.000	0.833	.003	19	view →
HNSC	DFS	Median	All	0.153	1.000	.038	18	view →
CCRCC	DFS	Median	II,III,IV	1.000	0.333	.014	5	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

THUMPD2–LSCC (DFS)

Open the LSCC breakdown →