THUMPD2

Across TCGA pan-cancer cohorts, THUMPD2 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of THUMPD2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where THUMPD2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types THUMPD2 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

COAD, KIRC, and LUAD are the cancer types where THUMPD2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in THUMPD2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+1.053	<.001	11	view →
KIRC	Male	All	+0.512	<.001	11	view →
LUAD	Male	II,III,IV	+0.853	<.001	9	view →
BLCA	Female	III,IV	+0.680	<.001	9	view →
KICH	Female	All	−1.492	<.001	8	view →
LIHC	Female	II,III,IV	+0.963	<.001	8	view →
HNSC	Male	IV	+0.899	<.001	8	view →
THCA	Male	All	−0.371	<.001	8	view →
READ	Female	All	+1.028	<.001	7	view →
STAD	All	II,III,IV	+0.643	<.001	6	view →
CHOL	Female	All	+2.313	<.001	5	view →
LUSC	Male	II,III,IV	+0.698	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

THUMPD2–COAD

Open the COAD breakdown →