THUMPD2

Across TCGA patient cohorts, THUMPD2 mutation is significantly associated with the RNA expression of many other genes, with 2,121 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THUMPD2-associated genes across cancer lineages are RNU2-42P, RNA5SP521, and KRTAP20-3. Each is linked with THUMPD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both THUMPD2-to-partner and partner-to-THUMPD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU2-42P grouped by THUMPD2-low versus THUMPD2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THUMPD2→partner) and Y-score (partner→THUMPD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU2-42P →	+0.323	+5.513	<.001	.004	3	2
BLCA	RNA5SP521 →	+0.588	+4.973	<.001	.009	3	2
UCEC	KRTAP20-3 →	+0.067	+4.060	<.001	.006	3	2
SKCM	OR4S2 →	+0.119	+7.485	<.001	<.001	3	1
SKCM	RNU6-230P →	+0.396	+5.680	<.001	.003	3	1
SKCM	RNU6-177P →	+0.484	+5.771	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,121 associations by consensus.

RNU2-42P by THUMPD2 expression — SKCM

Explore this box plot interactively →