THUMPD2

Across TCGA cell cohorts, THUMPD2 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible THUMPD2-associated genes across cancer lineages are ELOA3P, SLC6A5, and IL4. Each is linked with THUMPD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both THUMPD2-to-partner and partner-to-THUMPD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ELOA3P grouped by THUMPD2-low versus THUMPD2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THUMPD2→partner) and Y-score (partner→THUMPD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ELOA3P →	+0.106	+3.819	<.001	.003	3	2
LUNG_NSCLC_LUAD	SLC6A5 →	+0.019	+5.228	<.001	.005	3	1
SKIN	IL4 →	+0.073	+3.217	<.001	.006	3	1
SKIN	SLC9A2 →	+0.316	+3.541	.001	.004	3	1
SKIN	CYP2C8 →	+0.166	+3.662	.007	.005	3	1
SKIN	FAM135B →	+0.617	+3.442	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

ELOA3P by THUMPD2 expression — LARGE_INTESTINE

Explore this box plot interactively →