THUMPD1

Across TCGA pan-cancer cohorts, THUMPD1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated THUMPD1 data layer compared with 25 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher THUMPD1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated THUMPD1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

UCEC, LUAD, and PDAC are the cancer types where THUMPD1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	III,IV	0.246	1.000	.008	32	view →
LUAD	OS	Tertile	All	0.905	0.668	.006	28	view →
PDAC	DFS	Quartile	All	0.482	0.310	.015	16	view →
LSCC	OS	Median	II,III,IV	1.000	0.884	.021	9	view →
GBM	DFS	Median	All	0.446	0.299	.012	9	view →
HNSC	OS	Median	All	1.000	0.484	.038	6	view →
CCRCC	OS	Median	All	0.903	1.000	.013	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

THUMPD1–UCEC (DFS)

Open the UCEC breakdown →