THUMPD1

Across TCGA pan-cancer cohorts, THUMPD1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of THUMPD1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where THUMPD1 RNA is repressed in tumor relative to normal tissue. In most cancer types THUMPD1 is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

THCA, LIHC, and UCEC are the cancer types where THUMPD1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in THUMPD1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.004	<.001	10	view →
LIHC	All	II,III,IV	+0.641	<.001	8	view →
UCEC	All	All	−0.817	<.001	6	view →
KICH	All	All	−0.586	<.001	6	view →
KIRP	All	II,III,IV	+0.466	.002	6	view →
HNSC	All	All	+0.335	.006	6	view →
CHOL	All	All	+1.806	<.001	5	view →
BLCA	Male	IV	−0.454	.004	1	view →
COAD	Male	All	+0.284	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

THUMPD1–THCA

Open the THCA breakdown →