THUMPD1

Across TCGA patient cohorts, THUMPD1 mutation is significantly associated with the RNA expression of many other genes, with 319 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THUMPD1-associated genes across cancer lineages are MIR6075, ATP6V1G1P4, and OR10A5. Each is linked with THUMPD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both THUMPD1-to-partner and partner-to-THUMPD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6075 grouped by THUMPD1-low versus THUMPD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THUMPD1→partner) and Y-score (partner→THUMPD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6075 →	+0.293	+2.638	.004	.008	3	2
UCEC	ATP6V1G1P4 →	+0.347	+2.270	<.001	.007	3	2
BLCA	OR10A5 →	+0.093	+5.899	<.001	.002	3	1
UCEC	LSP1P1 →	+0.299	+2.535	.003	.005	3	1
UCEC	SMIM15P2 →	+0.857	+3.798	<.001	<.001	3	1
UCEC	PI4K2A →	+0.479	+3.191	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 319 associations by consensus.

MIR6075 by THUMPD1 expression — UCEC

Explore this box plot interactively →