THUMPD1

Across TCGA patient cohorts, THUMPD1 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THUMPD1-associated genes across cancer lineages are ERK2, GSK-3_pS9, and NF-kB-p65_pS536. Each is linked with THUMPD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both THUMPD1-to-partner and partner-to-THUMPD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by THUMPD1-low versus THUMPD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THUMPD1→partner) and Y-score (partner→THUMPD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.284	+3.321	.004	.010	3	1
UCEC	GSK-3_pS9 →	-0.499	-3.000	.018	.036	3	1
UCEC	NF-kB-p65_pS536 →	-0.557	-2.990	.019	.036	2	1
UCEC	EGFR_pY1068 →	-0.281	-3.321	.033	.010	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

ERK2 by THUMPD1 expression — UCEC

Explore this box plot interactively →