THTPA

Across TCGA pan-cancer cohorts, THTPA mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated THTPA data layer compared with 20 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher THTPA mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated THTPA expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

UCEC, PDAC, and CCRCC are the cancer types where THTPA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	II,III,IV	0.368	1.000	.004	28	view →
PDAC	DFS	Median	IV	0.785	0.214	.006	13	view →
CCRCC	DFS	Median	All	0.855	0.595	.028	6	view →
LUAD	DFS	Quartile	II,III,IV	1.000	0.221	.017	4	view →
GBM	DFS	Median	All	0.634	0.796	.012	3	view →
LSCC	DFS	Median	II,III,IV	1.000	0.571	.030	1	view →
HNSC	DFS	Median	IV	1.000	0.924	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

THTPA–UCEC (OS)

Open the UCEC breakdown →