THTPA

Across TCGA pan-cancer cohorts, THTPA RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of THTPA’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where THTPA RNA is repressed in tumor relative to normal tissue. In most cancer types THTPA is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and LIHC are the cancer types where THTPA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in THTPA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.809	<.001	11	view →
THCA	Male	III,IV	−0.835	<.001	10	view →
LIHC	Male	All	+0.828	<.001	9	view →
KICH	Male	All	−0.840	<.001	8	view →
KIRP	Male	All	−0.719	<.001	7	view →
UCEC	All	All	−0.723	.001	4	view →
CHOL	All	All	+1.154	<.001	3	view →
READ	All	All	−0.555	.014	2	view →
BRCA	Female	II,III,IV	−0.185	.043	2	view →
BLCA	Male	IV	−0.682	.044	1	view →
LUSC	All	III,IV	−0.613	.027	1	view →
COAD	All	IV	−0.430	.003	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

THTPA–KIRC

Open the KIRC breakdown →