THTPA

Across TCGA patient cohorts, THTPA mutation is significantly associated with the RNA expression of many other genes, with 318 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THTPA-associated genes across cancer lineages are RNU6-927P, MIR4510, and HARBI1. Each is linked with THTPA in more than 1 cancer types. Because this analysis shows association rather than direction, both THTPA-to-partner and partner-to-THTPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-927P grouped by THTPA-low versus THTPA-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THTPA→partner) and Y-score (partner→THTPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-927P →	+0.461	+5.017	.006	.009	3	2
PRAD	MIR4510 →	+0.348	+7.939	<.001	.008	3	1
UCEC	HARBI1 →	+0.407	+3.627	.008	.001	3	1
UCEC	NOP10 →	+0.510	+3.213	.003	.009	3	1
UCEC	KMT5A →	+0.484	+3.507	.003	.002	3	1
UCEC	ACTBP7 →	+0.586	+3.377	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 318 associations by consensus.

RNU6-927P by THTPA expression — COAD

Explore this box plot interactively →