THTPA

Across TCGA patient cohorts, THTPA mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THTPA-associated genes across cancer lineages are JNK_pT183_Y185, Ku80, and MEK1. Each is linked with THTPA in more than 1 cancer types. Because this analysis shows association rather than direction, both THTPA-to-partner and partner-to-THTPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by THTPA-low versus THTPA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THTPA→partner) and Y-score (partner→THTPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.168	-2.308	.047	.036	3	1
UCEC	Ku80 →	+0.252	+2.335	.033	.020	3	1
UCEC	MEK1 →	+0.490	+3.321	.007	.010	3	1
UCEC	p62 Lck ligand →	+0.338	+3.009	.039	.019	3	1
UCEC	Axl →	+0.217	+2.818	.036	.035	3	1
UCEC	C-Raf →	+0.151	+2.321	.036	.035	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

JNK_pT183_Y185 by THTPA expression — UCEC

Explore this box plot interactively →