THSD7B

Across TCGA patient cohorts, THSD7B mutation is significantly associated with the total protein of many other genes, with 104 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THSD7B-associated genes across cancer lineages are Caveolin-1, PKC-a_pS657, and c-Kit. Each is linked with THSD7B in more than 4 cancer types. Because this analysis shows association rather than direction, both THSD7B-to-partner and partner-to-THSD7B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caveolin-1 grouped by THSD7B-low versus THSD7B-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THSD7B→partner) and Y-score (partner→THSD7B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Caveolin-1 →	-0.769	-3.584	.003	.002	3	5
LUAD	PKC-a_pS657 →	-0.254	-1.966	.018	.027	3	5
COAD	c-Kit →	-0.631	-3.321	.002	.009	3	5
LUAD	mTOR_pS2448 →	-0.193	-2.402	.003	.003	3	4
COAD	PKC-b-II_pS660 →	-0.464	-3.807	<.001	<.001	3	4
UCEC	4E-BP1 →	+0.351	+1.788	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 104 associations by consensus.

Caveolin-1 by THSD7B expression — STAD

Explore this box plot interactively →