THSD7B

Across TCGA cell cohorts, THSD7B mutation is significantly associated with the RNA expression of many other genes, with 452 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible THSD7B-associated genes across cancer lineages are CCDC77, SIM1, and PRR30. Each is linked with THSD7B in more than 2 cancer types. Because this analysis shows association rather than direction, both THSD7B-to-partner and partner-to-THSD7B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC77 grouped by THSD7B-low versus THSD7B-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THSD7B→partner) and Y-score (partner→THSD7B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CCDC77 →	+0.601	+2.169	<.001	.004	3	3
LUNG_NSCLC_LUSC	SIM1 →	+0.068	+3.584	.002	.006	3	2
BLOOD_Leukemia	PRR30 →	+0.008	+2.684	<.001	.004	3	2
STOMACH	TBC1D28 →	+0.051	+3.754	.008	.005	3	2
STOMACH	PCDH11Y →	+0.036	+4.247	<.001	<.001	3	2
LARGE_INTESTINE	PIGL →	+0.648	+2.584	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 452 associations by consensus.

CCDC77 by THSD7B expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →