THSD7A

Across TCGA pan-cancer cohorts, THSD7A Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated THSD7A data layer compared with 23 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher THSD7A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated THSD7A expression acts as an unfavorable survival marker, although some lineages such as LUSC and UCEC show a favorable association.

READ, BLCA, and OV are the cancer types where THSD7A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Median	II,III,IV	0.111	0.919	<.001	27	view →
BLCA	OS	Median	IV	0.067	0.594	<.001	24	view →
OV	DFS	Median	All	0.304	0.543	.025	18	view →
LUSC	OS	Median	All	0.598	0.379	.007	14	view →
HNSC	OS	Median	All	0.303	0.618	.007	12	view →
SKCM	DFS	Median	III,IV	0.372	0.632	.006	11	view →
LIHC	DFS	Median	II,III,IV	0.077	0.463	.002	9	view →
UCEC	OS	Median	II,III,IV	0.933	0.458	.023	8	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
SARC	DFS	Median	All	0.206	0.597	.018	3	view →
BRCA	OS	Median	III,IV	0.633	0.908	.032	2	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

THSD7A–READ (OS)

Open the READ breakdown →