THSD7A

Across TCGA pan-cancer cohorts, THSD7A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated THSD7A data layer compared with 23 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher THSD7A mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated THSD7A expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

PDAC, LUAD, and HNSC are the cancer types where THSD7A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	II,III,IV	0.613	0.333	.028	6	view →
LUAD	OS	Quartile	II,III,IV	0.322	1.000	.020	4	view →
HNSC	OS	Quartile	All	0.930	0.802	.047	2	view →
LSCC	DFS	Quartile	II,III,IV	0.829	1.000	.030	1	view →
CCRCC	OS	Quartile	All	0.695	0.894	.036	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

THSD7A–PDAC (DFS)

Open the PDAC breakdown →