THSD7A

Across TCGA patient cohorts, THSD7A mutation is significantly associated with the RNA expression of many other genes, with 5,419 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THSD7A-associated genes across cancer lineages are AURKB, MAMDC2, and PCGF1. Each is linked with THSD7A in more than 4 cancer types. Because this analysis shows association rather than direction, both THSD7A-to-partner and partner-to-THSD7A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AURKB grouped by THSD7A-low versus THSD7A-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THSD7A→partner) and Y-score (partner→THSD7A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	AURKB →	+0.825	+1.860	<.001	<.001	3	5
LUAD	MAMDC2 →	-0.766	-1.847	.002	.008	3	5
LUSC	PCGF1 →	+0.246	+1.471	<.001	.006	3	4
UCEC	ALPL →	-1.475	-1.750	<.001	<.001	3	4
UCEC	SMIM4 →	+0.470	+1.968	<.001	<.001	3	4
STAD	C1QBP →	+1.080	+3.717	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,419 associations by consensus.

AURKB by THSD7A expression — LUAD

Explore this box plot interactively →