THSD7A

Across TCGA cell cohorts, THSD7A mutation is significantly associated with the RNA expression of many other genes, with 650 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible THSD7A-associated genes across cancer lineages are HINT3, MTHFD2L, and BTBD8. Each is linked with THSD7A in more than 2 cancer types. Because this analysis shows association rather than direction, both THSD7A-to-partner and partner-to-THSD7A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HINT3 grouped by THSD7A-low versus THSD7A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THSD7A→partner) and Y-score (partner→THSD7A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HINT3 →	+0.716	+2.212	<.001	<.001	3	3
LARGE_INTESTINE	MTHFD2L →	+0.468	+3.404	.005	<.001	3	3
SKIN	BTBD8 →	+0.504	+3.364	<.001	.002	3	3
PANCREAS	KRTAP20-2 →	+0.126	+5.614	<.001	.002	3	2
LUNG_NSCLC_LUAD	CSPG5 →	+0.906	+2.513	<.001	.004	3	2
SKIN	CLTA →	-0.474	-3.102	.006	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 650 associations by consensus.

HINT3 by THSD7A expression — LARGE_INTESTINE

Explore this box plot interactively →