Across TCGA patient cohorts, THSD4 protein abundance is significantly associated with the RNA expression of many other genes, with 14,616 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible THSD4-associated genes across cancer lineages are PGR, RBMS3, and CX3CR1. Each is linked with THSD4 in more than 5 cancer types. Because this analysis shows association rather than direction, both THSD4-to-partner and partner-to-THSD4 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THSD4→partner) and Y-score (partner→THSD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PGR →	+2.235	+0.815	<.001	<.001	3	6
PDAC	RBMS3 →	+0.832	+0.619	<.001	<.001	3	6
BRCA	CX3CR1 →	+1.277	+0.824	<.001	<.001	3	6
LUAD	FCER1A →	+1.318	+0.526	<.001	<.001	3	6
CCRCC	FOXS1 →	+1.068	+0.660	<.001	<.001	3	6
GBM	EPHA3 →	+1.269	+0.579	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,616 associations by consensus.

Exploration

THSD4 survival (RNA) · tumor vs normal (RNA) · all THSD4 data types