Across TCGA patient cohorts, THSD4 mutation is significantly associated with the RNA expression of many other genes, with 5,691 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THSD4-associated genes across cancer lineages are TIMM44, STAU2P1, and SNRPD3. Each is linked with THSD4 in more than 3 cancer types. Because this analysis shows association rather than direction, both THSD4-to-partner and partner-to-THSD4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THSD4→partner) and Y-score (partner→THSD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIMM44 →	+0.332	+1.579	<.001	<.001	3	4
LUAD	STAU2P1 →	+0.077	+2.755	.005	.009	3	3
SKCM	SNRPD3 →	+0.264	+1.321	<.001	.001	3	3
SKCM	FBXO7 →	+0.438	+2.417	<.001	<.001	3	3
SKCM	RHBDD3 →	+0.331	+2.726	.001	<.001	3	3
SKCM	EIF3D →	+0.268	+1.485	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,691 associations by consensus.

Exploration

THSD4 survival (RNA) · tumor vs normal (RNA) · all THSD4 data types