Across TCGA patient cohorts, THSD4 mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THSD4-associated genes across cancer lineages are MYH11, Caspase-7-cleavedD198, and eIF4E. Each is linked with THSD4 in more than 3 cancer types. Because this analysis shows association rather than direction, both THSD4-to-partner and partner-to-THSD4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THSD4→partner) and Y-score (partner→THSD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	MYH11 →	-1.554	-3.000	.026	.034	2	4
STAD	Caspase-7-cleavedD198 →	+1.016	+3.000	.003	.034	3	3
UCEC	eIF4E →	+0.183	+1.847	.001	<.001	3	3
STAD	GAPDH →	+0.460	+3.169	.004	.018	3	2
STAD	Caveolin-1 →	-0.767	-3.000	.030	.034	3	2
STAD	c-Kit →	-0.432	-3.321	.003	.010	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

Exploration

THSD4 survival (RNA) · tumor vs normal (RNA) · all THSD4 data types