THSD1

Across TCGA patient cohorts, THSD1 mutation is significantly associated with the RNA expression of many other genes, with 2,743 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THSD1-associated genes across cancer lineages are OR5T2, PSMC3IP, and NIP7. Each is linked with THSD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both THSD1-to-partner and partner-to-THSD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5T2 grouped by THSD1-low versus THSD1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THSD1→partner) and Y-score (partner→THSD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	OR5T2 →	+0.027	+5.579	<.001	.001	3	3
UCEC	PSMC3IP →	+0.560	+1.898	<.001	.001	3	3
SKCM	NIP7 →	+0.474	+2.632	.008	.005	3	3
UCEC	PSMB7 →	+0.365	+3.621	<.001	<.001	3	3
SKCM	EXOSC2 →	+0.425	+2.536	.005	.008	3	3
SKCM	NPC1 →	+0.731	+3.478	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,743 associations by consensus.

OR5T2 by THSD1 expression — CESC

Explore this box plot interactively →