THSD1

Across TCGA pan-cancer cohorts, THSD1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of THSD1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where THSD1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types THSD1 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

HNSC, LUAD, and KIRC are the cancer types where THSD1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in THSD1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+3.146	<.001	12	view →
LUAD	Female	III,IV	−2.338	<.001	11	view →
KIRC	Female	All	+1.120	<.001	11	view →
LUSC	All	III,IV	−1.974	<.001	8	view →
KIRP	All	All	−0.684	<.001	8	view →
UCEC	All	All	−1.753	<.001	6	view →
BRCA	All	II,III,IV	−1.268	<.001	6	view →
KICH	Female	All	−1.051	<.001	5	view →
LIHC	All	All	+0.540	<.001	5	view →
CHOL	All	All	+0.947	.005	4	view →
THCA	All	IV	−0.887	<.001	4	view →
READ	Male	All	+0.806	.022	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

THSD1–HNSC

Open the HNSC breakdown →