THSD1

Across TCGA cell cohorts, THSD1 protein abundance is significantly associated with the go_rna of many other GO terms, with 1,691 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible THSD1-associated GO terms across cancer lineages are Aromatic amino acid metabolic process, 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process, and Fatty acid alpha-oxidation. Each is linked with THSD1 in more than 4 cancer types. Because this analysis shows association rather than direction, both THSD1-to-partner and partner-to-THSD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Aromatic amino acid metabolic process grouped by THSD1-low versus THSD1-high in SKIN.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (THSD1→partner) and Y-score (partner→THSD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Aromatic amino acid metabolic process →	+0.174	+0.682	.004	<.001	3	5
BLOOD_Leukemia	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process →	-0.101	-0.746	<.001	.003	3	5
LUNG_NSCLC_LUSC	Fatty acid alpha-oxidation →	+0.251	+1.400	<.001	<.001	3	5
PANCREAS	Mitochondrial mRNA polyadenylation →	+0.129	+1.017	.006	.005	3	4
LUNG_NSCLC_LUAD	RNA import into mitochondrion →	+0.110	+0.701	.003	.002	3	4
LUNG_NSCLC_LUAD	Protein import into mitochondrial intermembrane space →	+0.086	+0.782	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,691 associations by consensus.

Aromatic amino acid metabolic process by THSD1 expression — SKIN

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