THSD1

Across TCGA cell cohorts, THSD1 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible THSD1-associated genes across cancer lineages are REG1B, SLC6A19, and PCCB. Each is linked with THSD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both THSD1-to-partner and partner-to-THSD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG1B grouped by THSD1-low versus THSD1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THSD1→partner) and Y-score (partner→THSD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	REG1B →	+2.588	+2.518	<.001	.006	3	2
LARGE_INTESTINE	SLC6A19 →	+1.337	+3.302	<.001	.008	3	2
LARGE_INTESTINE	PCCB →	+0.749	+3.125	<.001	.008	3	1
LARGE_INTESTINE	CPLX4 →	+0.025	+2.444	<.001	.008	3	1
LARGE_INTESTINE	SMIM33 →	+0.603	+3.577	<.001	.002	3	1
LARGE_INTESTINE	NEXMIF →	+0.188	+2.518	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

REG1B by THSD1 expression — LARGE_INTESTINE

Explore this box plot interactively →