THRA

Across TCGA patient cohorts, THRA mutation is significantly associated with the RNA expression of many other genes, with 2,791 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THRA-associated genes across cancer lineages are RNU6-898P, LAP3P2, and TMEM237. Each is linked with THRA in more than 1 cancer types. Because this analysis shows association rather than direction, both THRA-to-partner and partner-to-THRA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-898P grouped by THRA-low versus THRA-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THRA→partner) and Y-score (partner→THRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-898P →	+0.174	+3.867	<.001	.002	3	2
SKCM	LAP3P2 →	+0.051	+2.725	<.001	.006	3	2
UCEC	TMEM237 →	+0.475	+3.000	.004	<.001	3	2
UCEC	TMEM183A →	+0.470	+3.010	.001	<.001	3	2
UCEC	MSANTD3 →	+0.685	+3.654	<.001	<.001	3	2
UCEC	IDI1 →	+0.507	+2.148	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,791 associations by consensus.

RNU6-898P by THRA expression — SKCM

Explore this box plot interactively →