THRA

Across TCGA patient cohorts, THRA mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THRA-associated genes across cancer lineages are p90 RSK, ATM, and EGFR_pY1068. Each is linked with THRA in more than 1 cancer types. Because this analysis shows association rather than direction, both THRA-to-partner and partner-to-THRA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p90 RSK grouped by THRA-low versus THRA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THRA→partner) and Y-score (partner→THRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p90 RSK →	+0.154	+1.884	.036	.030	3	2
UCEC	ATM →	-0.554	-2.584	.001	.001	3	2
UCEC	EGFR_pY1068 →	-0.223	-1.678	.020	.023	3	1
UCEC	ERK2 →	+0.163	+1.678	.027	.023	3	1
UCEC	JNK_pT183_Y185 →	-0.202	-2.074	.001	.005	3	1
UCEC	JNK2 →	+0.309	+3.817	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

p90 RSK by THRA expression — UCEC

Explore this box plot interactively →