THRA

Across TCGA cell cohorts, THRA RNA expression is significantly associated with the go_rna of many other GO terms, with 3,430 significant associations in total. CNS shows the largest number of these associations.

The most reproducible THRA-associated GO terms across cancer lineages are Thyroid hormone receptor signaling pathway, Regulation of thyroid hormone receptor signaling pathway, and Positive regulation of thyroid hormone receptor signaling pathway. Each is linked with THRA in more than 16 cancer types. Because this analysis shows association rather than direction, both THRA-to-partner and partner-to-THRA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Thyroid hormone receptor signaling pathway grouped by THRA-low versus THRA-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (THRA→partner) and Y-score (partner→THRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Thyroid hormone receptor signaling pathway →	+0.304	+1.737	.001	<.001	3	17
BLOOD_Lymphoma	Regulation of thyroid hormone receptor signaling pathway →	+0.954	+1.735	<.001	<.001	3	16
BLOOD_Lymphoma	Positive regulation of thyroid hormone receptor signaling pathway →	+0.954	+1.735	<.001	<.001	3	16
STOMACH	Fatty acid catabolic process →	+0.068	+1.499	.007	.003	3	13
UPPER_AERODIGESTIVE_TRACT	mRNA transcription by RNA polymerase II →	+0.070	+0.877	<.001	.001	3	12
KIDNEY	Aerobic respiration →	+0.072	+1.474	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,430 associations by consensus.

Thyroid hormone receptor signaling pathway by THRA expression — BREAST

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