THRA

Across TCGA cell cohorts, THRA mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible THRA-associated genes across cancer lineages are PTH, HTR1E, and HSFY2. Each is linked with THRA in more than 1 cancer types. Because this analysis shows association rather than direction, both THRA-to-partner and partner-to-THRA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTH grouped by THRA-low versus THRA-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THRA→partner) and Y-score (partner→THRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PTH →	+0.049	+3.684	<.001	.006	3	1
LARGE_INTESTINE	HTR1E →	+0.085	+3.930	<.001	.003	3	1
LARGE_INTESTINE	HSFY2 →	+0.015	+4.562	<.001	<.001	3	1
LARGE_INTESTINE	TPD52L3 →	+0.051	+3.684	<.001	.006	3	1
LARGE_INTESTINE	AMELY →	+0.036	+4.437	<.001	.004	3	1
BLOOD_Leukemia	EPPIN →	+0.006	+4.922	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

PTH by THRA expression — LARGE_INTESTINE

Explore this box plot interactively →