THPO

Across TCGA pan-cancer cohorts, THPO mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of THPO’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where THPO mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types THPO is over-expressed in tumor.

LSCC, HNSC, and LUAD are the cancer types where THPO tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in THPO mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	All	+1.887	<.001	9	view →
HNSC	Male	III,IV	+0.688	<.001	8	view →
LUAD	All	All	+0.803	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

THPO–LSCC

Open the LSCC breakdown →