THOP1

Across TCGA patient cohorts, THOP1 RNA expression is significantly associated with the protein abundance of many other proteins, with 20,886 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible THOP1-associated proteins across cancer lineages are CHAF1B, SMC4, and MCM2. Each is linked with THOP1 in more than 7 cancer types. Because this analysis shows association rather than direction, both THOP1-to-partner and partner-to-THOP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, THOP1 versus CHAF1B in GBM, with a Pearson correlation of 0.52.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (THOP1→partner) and Y-score (partner→THOP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CHAF1B →	+0.853	+0.506	<.001	<.001	3	8
LUAD	SMC4 →	+0.544	+0.511	<.001	<.001	3	8
GBM	MCM2 →	+0.808	+0.400	<.001	<.001	3	8
LUAD	MCM2_S139 →	+0.931	+0.531	<.001	<.001	3	8
GBM	MCM4 →	+0.857	+0.417	<.001	<.001	3	8
COAD	CHAF1A →	+1.344	+0.837	<.001	.007	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,886 associations by consensus.

THOP1 vs CHAF1B — GBM

Explore this scatter interactively →