THOC7

Across TCGA pan-cancer cohorts, THOC7 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of THOC7’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where THOC7 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types THOC7 is over-expressed in tumor.

COAD, LSCC, and LUAD are the cancer types where THOC7 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in THOC7 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	+0.341	<.001	10	view →
LSCC	Male	All	+0.519	<.001	9	view →
LUAD	Male	All	+0.457	<.001	9	view →
HNSC	Male	IV	+0.320	<.001	8	view →
CCRCC	Male	All	+0.097	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

THOC7–COAD

Open the COAD breakdown →