THOC5

Across TCGA patient cohorts, THOC5 mutation is significantly associated with the RNA expression of many other genes, with 2,016 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THOC5-associated genes across cancer lineages are CDCA2, PSMA4, and MRPL22. Each is linked with THOC5 in more than 2 cancer types. Because this analysis shows association rather than direction, both THOC5-to-partner and partner-to-THOC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDCA2 grouped by THOC5-low versus THOC5-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THOC5→partner) and Y-score (partner→THOC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CDCA2 →	+0.835	+3.183	<.001	.009	3	3
UCEC	PSMA4 →	+0.390	+2.424	.004	<.001	3	3
UCEC	MRPL22 →	+0.299	+2.065	.002	.004	3	3
UCEC	EIF3I →	+0.318	+3.754	.001	<.001	3	3
UCEC	DNAJC8 →	+0.373	+3.716	.001	<.001	3	3
UCEC	RNU1-153P →	-0.759	-3.000	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,016 associations by consensus.

CDCA2 by THOC5 expression — COAD

Explore this box plot interactively →