THOC5

Across TCGA pan-cancer cohorts, THOC5 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of THOC5’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where THOC5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types THOC5 is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.

HNSC, COAD, and KIRC are the cancer types where THOC5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in THOC5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.894	<.001	12	view →
COAD	Female	All	+0.589	<.001	11	view →
KIRC	Female	All	+0.497	<.001	11	view →
LIHC	Female	II,III,IV	+1.567	<.001	9	view →
THCA	Male	All	+0.831	<.001	9	view →
LUAD	Male	II,III,IV	+0.443	<.001	7	view →
LUSC	Female	All	+0.886	<.001	6	view →
CHOL	Male	All	+2.255	<.001	5	view →
STAD	Male	II,III,IV	+0.724	<.001	4	view →
READ	Male	All	+0.313	.004	4	view →
BRCA	Female	All	−0.128	.018	4	view →
KICH	Female	All	−0.782	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

THOC5–HNSC

Open the HNSC breakdown →