THOC5

Across TCGA patient cohorts, THOC5 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THOC5-associated genes across cancer lineages are INPP4B, MEK1, and p70-S6K. Each is linked with THOC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both THOC5-to-partner and partner-to-THOC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by THOC5-low versus THOC5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THOC5→partner) and Y-score (partner→THOC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.260	-2.459	.032	.018	3	2
UCEC	MEK1 →	+0.508	+2.906	<.001	.001	3	2
UCEC	p70-S6K →	+0.155	+2.604	.031	.005	3	2
UCEC	ATM →	-0.737	-2.662	<.001	<.001	3	2
COAD	Caspase-7-cleavedD198 →	+0.854	+2.330	.016	.020	3	2
UCEC	4E-BP1 →	+0.351	+2.614	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

INPP4B by THOC5 expression — UCEC

Explore this box plot interactively →