THOC5

Across TCGA cell cohorts, THOC5 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,027 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible THOC5-associated GO terms across cancer lineages are IMP biosynthetic process, DNA-templated transcription initiation, and Transcription initiation at RNA polymerase I promoter. Each is linked with THOC5 in more than 12 cancer types. Because this analysis shows association rather than direction, both THOC5-to-partner and partner-to-THOC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IMP biosynthetic process grouped by THOC5-low versus THOC5-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (THOC5→partner) and Y-score (partner→THOC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	IMP biosynthetic process →	+0.206	+1.101	.002	.002	3	13
UPPER_AERODIGESTIVE_TRACT	DNA-templated transcription initiation →	+0.083	+0.865	.001	.003	3	13
LARGE_INTESTINE	Transcription initiation at RNA polymerase I promoter →	+0.123	+0.784	.002	.003	3	13
LARGE_INTESTINE	XMP metabolic process →	+0.141	+1.028	<.001	<.001	3	13
LARGE_INTESTINE	XMP biosynthetic process →	+0.141	+1.028	<.001	<.001	3	13
LARGE_INTESTINE	'de novo' XMP biosynthetic process →	+0.141	+1.028	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,027 associations by consensus.

IMP biosynthetic process by THOC5 expression — URINARY_TRACT

Explore this box plot interactively →