THOC3

Across TCGA pan-cancer cohorts, THOC3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated THOC3 data layer compared with 22 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher THOC3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated THOC3 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

CCRCC, COAD, and HNSC are the cancer types where THOC3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.580	0.940	<.001	40	view →
COAD	DFS	Median	IV	0.493	0.944	.031	6	view →
HNSC	DFS	Median	All	0.698	1.000	.020	6	view →
LUAD	DFS	Quartile	III,IV	1.000	0.330	.028	6	view →
LSCC	DFS	Tertile	II,III,IV	0.882	0.515	.025	5	view →
PDAC	OS	Median	IV	0.962	0.488	.048	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

THOC3–CCRCC (DFS)

Open the CCRCC breakdown →