THOC3

Across TCGA cell cohorts, THOC3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,662 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible THOC3-associated GO terms across cancer lineages are Metaphase/anaphase transition of cell cycle, Metaphase/anaphase transition of mitotic cell cycle, and Cell cycle checkpoint signaling. Each is linked with THOC3 in more than 13 cancer types. Because this analysis shows association rather than direction, both THOC3-to-partner and partner-to-THOC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Metaphase/anaphase transition of cell cycle grouped by THOC3-low versus THOC3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (THOC3→partner) and Y-score (partner→THOC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Metaphase/anaphase transition of cell cycle →	+0.188	+0.879	.006	.007	3	14
BONE	Metaphase/anaphase transition of mitotic cell cycle →	+0.182	+0.879	.007	.007	3	13
BLOOD_Myeloma	Cell cycle checkpoint signaling →	+0.081	+1.285	<.001	<.001	3	12
BLOOD_Myeloma	Negative regulation of cell cycle process →	+0.058	+1.157	.003	<.001	2	13
BONE	Mitotic DNA replication →	+0.230	+0.961	.001	.004	3	12
BONE	Nuclear DNA replication →	+0.157	+0.820	.005	.004	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,662 associations by consensus.

Metaphase/anaphase transition of cell cycle by THOC3 expression — BONE

Explore this box plot interactively →