THOC3

Across TCGA cell cohorts, THOC3 mutation is significantly associated with the mutation status of many other genes, with 2,022 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible THOC3-associated genes across cancer lineages are PNKP, ADAM22, and MAG. Each is linked with THOC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both THOC3-to-partner and partner-to-THOC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PNKP grouped by THOC3-low versus THOC3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THOC3→partner) and Y-score (partner→THOC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PNKP →	+4.744	+5.459	<.001	<.001	1	2
LARGE_INTESTINE	ADAM22 →	+2.574	+4.182	.003	.003	1	2
BLOOD_Leukemia	MAG →	+4.321	+5.285	.005	.005	1	2
BLOOD_Leukemia	PLOD3 →	+4.736	+5.560	.003	.003	1	2
BLOOD_Leukemia	MTPAP →	+4.321	+5.285	.005	.005	1	2
BLOOD_Leukemia	KPNB1 →	+4.000	+5.050	.008	.008	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,022 associations by consensus.

PNKP by THOC3 expression — LARGE_INTESTINE

Explore this box plot interactively →