THOC1

Across TCGA patient cohorts, THOC1 mutation is significantly associated with the RNA expression of many other genes, with 1,979 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THOC1-associated genes across cancer lineages are RN7SL248P, SNORD114-10, and RNU6-651P. Each is linked with THOC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both THOC1-to-partner and partner-to-THOC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by THOC1-low versus THOC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THOC1→partner) and Y-score (partner→THOC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.044	+2.783	<.001	.009	3	3
SKCM	SNORD114-10 →	+0.953	+5.224	<.001	.007	3	2
SKCM	RNU6-651P →	+0.688	+5.097	<.001	.008	3	2
UCEC	IGLJ7 →	+0.957	+2.053	<.001	<.001	3	2
CESC	RNA5SP369 →	+0.495	+4.539	<.001	.008	3	2
BRCA	SPATA31E3P →	+0.006	+4.721	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,979 associations by consensus.

RN7SL248P by THOC1 expression — UCEC

Explore this box plot interactively →