THOC1

Across TCGA cell cohorts, THOC1 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible THOC1-associated genes across cancer lineages are COL6A5, OR2M4, and GPR148. Each is linked with THOC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both THOC1-to-partner and partner-to-THOC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COL6A5 grouped by THOC1-low versus THOC1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THOC1→partner) and Y-score (partner→THOC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	COL6A5 →	+0.065	+3.760	<.001	.008	3	2
OVARY	OR2M4 →	+0.055	+3.700	.001	.005	3	1
OVARY	GPR148 →	+0.056	+4.095	<.001	.003	3	1
OVARY	OR4C6 →	+0.087	+3.791	.003	.007	3	1
LARGE_INTESTINE	TEX101 →	+0.172	+3.708	<.001	.004	3	1
LARGE_INTESTINE	POU4F2 →	+0.008	+2.791	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

COL6A5 by THOC1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →