THG1L

Across TCGA pan-cancer cohorts, THG1L mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated THG1L data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher THG1L mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated THG1L expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LSCC, LUAD, and PDAC are the cancer types where THG1L mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	III,IV	0.528	0.923	.007	18	view →
LUAD	DFS	Median	All	0.955	0.846	.014	5	view →
PDAC	OS	Median	IV	0.836	0.491	.024	3	view →
GBM	DFS	Median	All	0.282	0.452	.015	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

THG1L–LSCC (OS)

Open the LSCC breakdown →