THG1L

Across TCGA pan-cancer cohorts, THG1L RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of THG1L’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where THG1L RNA is more highly expressed in tumor relative to normal tissue. In most cancer types THG1L is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

KIRC, KIRP, and LIHC are the cancer types where THG1L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in THG1L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+1.079	<.001	11	view →
KIRP	Male	II,III,IV	+0.718	.002	8	view →
LIHC	Female	All	+0.594	<.001	8	view →
COAD	Female	All	+0.570	<.001	8	view →
KICH	Female	All	−1.348	<.001	5	view →
UCEC	All	All	−0.606	.002	4	view →
HNSC	All	All	+0.276	.007	4	view →
CHOL	Female	All	+1.946	<.001	3	view →
READ	All	II,III,IV	+0.474	.036	1	view →
THCA	All	All	−0.180	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

THG1L–KIRC

Open the KIRC breakdown →