THG1L

Across TCGA patient cohorts, THG1L protein abundance is significantly associated with the RNA expression of many other genes, with 10,989 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible THG1L-associated genes across cancer lineages are NPM1, NOP16, and RUFY1. Each is linked with THG1L in more than 4 cancer types. Because this analysis shows association rather than direction, both THG1L-to-partner and partner-to-THG1L results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, THG1L versus NPM1 in OV, with a Pearson correlation of 0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THG1L→partner) and Y-score (partner→THG1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NPM1 →	+0.819	+0.390	<.001	<.001	3	5
OV	NOP16 →	+0.536	+0.313	.001	<.001	3	5
OV	RUFY1 →	+0.512	+0.255	.002	.007	3	4
OV	RACK1 →	+0.860	+0.460	<.001	<.001	3	4
LSCC	ANKRD40 →	-0.379	-0.159	.002	.004	3	4
HNSC	GPRC5B →	-0.783	-0.232	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,989 associations by consensus.

THG1L vs NPM1 — OV

Explore this scatter interactively →