THG1L

Across TCGA patient cohorts, THG1L mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THG1L-associated genes across cancer lineages are FOXO3a, MEK1, and PDCD4. Each is linked with THG1L in more than 1 cancer types. Because this analysis shows association rather than direction, both THG1L-to-partner and partner-to-THG1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a grouped by THG1L-low versus THG1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THG1L→partner) and Y-score (partner→THG1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a →	+0.135	+3.183	.015	.010	3	1
UCEC	MEK1 →	+0.449	+3.169	.025	.020	3	1
UCEC	PDCD4 →	-0.582	-3.169	.024	.020	2	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

FOXO3a by THG1L expression — UCEC

Explore this box plot interactively →