THG1L

Across TCGA cell cohorts, THG1L RNA expression is significantly associated with the go_rna of many other GO terms, with 3,016 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible THG1L-associated GO terms across cancer lineages are tRNA 5'-end processing, RNA 5'-end processing, and Mitochondrial translation. Each is linked with THG1L in more than 14 cancer types. Because this analysis shows association rather than direction, both THG1L-to-partner and partner-to-THG1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, tRNA 5'-end processing grouped by THG1L-low versus THG1L-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (THG1L→partner) and Y-score (partner→THG1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	tRNA 5'-end processing →	+0.117	+0.921	<.001	<.001	3	15
OVARY	RNA 5'-end processing →	+0.101	+0.983	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Mitochondrial translation →	+0.068	+0.536	.004	.004	3	8
SOFT_TISSUE	tRNA surveillance →	+0.084	+0.406	<.001	.007	3	8
OVARY	Mitochondrial small ribosomal subunit assembly →	+0.076	+0.627	.001	.008	3	8
SOFT_TISSUE	RNA modification →	+0.037	+0.574	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,016 associations by consensus.

tRNA 5'-end processing by THG1L expression — BLOOD_Myeloma

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