THG1L

Across TCGA cell cohorts, THG1L mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible THG1L-associated genes across cancer lineages are SLC16A12, GPR26, and SMIM34A. Each is linked with THG1L in more than 1 cancer types. Because this analysis shows association rather than direction, both THG1L-to-partner and partner-to-THG1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC16A12 grouped by THG1L-low versus THG1L-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THG1L→partner) and Y-score (partner→THG1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLC16A12 →	+0.588	+3.710	.001	.008	3	1
LARGE_INTESTINE	GPR26 →	+0.021	+2.925	<.001	.007	3	1
LARGE_INTESTINE	SMIM34A →	+0.179	+3.520	<.001	.005	3	1
BREAST	CETN1 →	+0.005	+4.781	<.001	.003	3	1
BLOOD_Leukemia	GOT1L1 →	+0.060	+5.569	<.001	.001	3	1
BLOOD_Leukemia	RBMY1D →	+0.179	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

SLC16A12 by THG1L expression — LARGE_INTESTINE

Explore this box plot interactively →