THEMIS3P

Across TCGA pan-cancer cohorts, THEMIS3P RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated THEMIS3P data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher THEMIS3P RNA is associated with better overall survival. In most high-consensus cancer types, elevated THEMIS3P expression acts as an unfavorable survival marker, although some lineages such as HNSC and BLCA show a favorable association.

HNSC, STAD, and LGG are the cancer types where THEMIS3P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.585	0.341	.003	66	view →
STAD	DFS	Tertile	II,III,IV	0.459	0.754	<.001	61	view →
LGG	DFS	Tertile	All	0.655	0.786	<.001	54	view →
LAML	DFS	Tertile	All	0.397	0.649	<.001	38	view →
BLCA	OS	Median	IV	0.727	0.517	.005	35	view →
KICH	OS	Tertile	All	0.477	0.891	.010	30	view →
READ	DFS	Tertile	II,III,IV	0.111	0.793	.001	21	view →
MESO	OS	Tertile	II,III,IV	0.247	0.420	.029	18	view →
UCS	DFS	Quartile	II,III,IV	0.727	0.337	.014	18	view →
LUSC	DFS	Median	III,IV	0.524	0.270	.010	15	view →
GBM	OS	Median	All	0.290	0.508	.005	12	view →
KIRC	DFS	Tertile	IV	0.704	0.342	.019	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

THEMIS3P–HNSC (OS)

Open the HNSC breakdown →