THEMIS3P

Across TCGA pan-cancer cohorts, THEMIS3P RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of THEMIS3P’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where THEMIS3P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types THEMIS3P is over-expressed in tumor, although a few such as LUSC and KICH show the opposite, repressed pattern.

HNSC, LUSC, and THCA are the cancer types where THEMIS3P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in THEMIS3P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	II,III,IV	+0.100	.020	6	view →
LUSC	Male	II,III,IV	−0.155	<.001	5	view →
THCA	All	All	+0.030	.015	4	view →
KICH	All	All	−0.035	.007	2	view →
UCEC	All	All	+0.027	.042	2	view →
BLCA	Female	III,IV	+0.084	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

THEMIS3P–HNSC

Open the HNSC breakdown →